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Here's the difference between jpeg and TIFF. I scanned an image of Yoko from Gurren Lagann that is 5x3.5 @ 600dpi and 1200dpi. Both images came out at 2987x2074 @600dpi. The jpeg topped out at 3.45mb while the TIFF topped out at 17.8mb. And at 1200dpi the images came out at 5974x4148 but the jpeg was 34.1mb and the TIFF file was 70.9mb. My scanner doesn't output to PNG so I can't show the difference there. My old one did but not this one. So output is dependant on how much drive space you have. If you have lots of hard drive space, or don't plan on keeping them for very long, by all means save them as TIFF's. Or if you plan on doing image manipulation TIFF would be the way to go. Then again, it's all up to the person doing the scanning ...