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I've actually started using some of my monitors in portrait mode at work because of a picture cakes posted a while back. I don't know why I didn't try it earlier, because I can't work without it now. I have the same basic setup with portrait monitors on either side of my widescreen main monitor, and they're awesome for emails, documents, specs, PDFs (I can actually view a whole page at a readable zoom level now), etc. while my main screen is almost always my code editor in full screen mode that covers everything, including the taskbar.

In short, it made my multimonitor setup at work even more useful than it was previously.