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Please clarify if these should remain separate and tagged accordingly or whether they need a tag implication instead where all avatars have their real name implicated/tagged as well. (For example leafa will need to implicate kirigaya_suguha even though hair color and style as well as eye color are all different)

Basically same character, main difference is eye color. Danbooru does not differentiate and does not have a tag for for their real life counterparts
tozawa_misumi > mito_(sword_art_online)
ayano_keiko > silica

Debatable: Both hair and eye color are different, but generally retains same hair style
Danbooru differentiates between asada_shino and sinon, but not for lisbeth_(sao) since technically, she starts out with brown hair in-game
shinozaki_rika > lisbeth
asada_shino > sinon