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@billyboy12 TBH that thing FUCKING SUUUCKS. Constant intrusive pop-ups and NOISE. And the output is SHIT.
It preserves noise artifacts and erases image details. Maybe the models aren't configured properly, but I was unable to get it to output any good quality images.

I use this simple thing: https://github.com/YukihoAA/waifu2x_snowshell
Less noise, more details. GRANTED, it is only for images, but holy fuck is the quality so much better, regardless of the model you choose.

snowshell
- Pros: No intrusive pop-ups, noise, better quality output.
- Cons: Only images, limits what scale you can use of some models.
Extension-GUI
- Pros: Can do video, can use any scale on any? model, more models to choose from.
- Cons: Pop-ups and NOISE. Shitty output.

Edit: Some more interesting findings:
CUGAN seems to really want straight, high-contrast lines. But that sometimes erases details or makes things up. It's also kinda noisy.
Caffe preserves a lot of details, but is blurrier/less sharp.
So... what I found is that Caffe 2x -> CUGAN 2x is almost universally better than just Caffe 4x or CUGAN 4x. (The order is important btw.)
P.S. ESRGAN just sucks (for anime anyway).